The intermediates
The material for the synthesis of ghost mortar poison class API needed intermediates, its quality and cost is directly related to its subsequent API quality and cost, play a decisive role throughout the synthesis action . Through trial and error, we developed a novel preparation of high purity, 4'-Demethylepipodophyllotoxin process routes, no hydrogen bromide, use strong acid demethylation and hydrolysis, abolish the halogen containing solvents and hydrogen bromide gas,only one step,we can made high purity (HPLC99.5 % ~ 99.9%) 4'-Demethylepipodophyllotoxin with mild reaction conditions, simple to equipment requirement, safety and environmental protection, and is suitable for industrialized production, significantly increased yield of older technology, production cost is reduced, this is a very competitive products, huge market at the world.